2002

A new material for the microencapsulation of biological systems was discovered and characterized with regards to the effects of reaction conditions on product yield. By using poly(cyanoacrylate ester), membrane microcapsules were produced with sufficient strength and porosity to be effective in a process environment for the immobilization and protection of encapsulated material. After synthesizing numerous monomeric cyanoacrylate esters, the n-butyl derivative was discovered to give the best results with regards to microcapsule formation.

A catalyst generated in situ from palladium acetate and tricyclohexylphosphine efficiently catalyzes the reduction of carboxylic acids with sodium hypophosphite in the presence of pivalic anhydride to give aldehydes with high selectivity. The low cost and convenient handling of the reagents makes this process a valuable alternative to hydrogenations and metal hydride reductions.

A sterile or non-sterile flavored monomeric adhesive composition includes a flavoring additive and a monomer. The composition can be applied, for example, to skin or the inside of the mouth. A method of making a sterile, flavored adhesive composition includes placing a mixture of a polymerizable adhesive monomer and a flavoring additive in a container, sealing the container, and sterilizing the mixture and the container. The flavored adhesive composition is particularly useful as a medical adhesive and can include 1,1 -disubstituted ethylene monomers, such as -cyanoacrylates.

An adhesive composition that contains cyanoacrylate monomers and cyclic or alkyl- or phenyl-terminated linear polydimethylsiloxane is particularly useful in applications requiring flexibility and elasticity. A method of removing, reducing or preventing scar tissue including applying an adhesive composition that contains cyanoacrylate monomer and cyclic or alkyl- or phenyl-terminated linear polydimethylsiloxane.

A composition comprising a polymerizable adhesive monomer is applied over a biologically active initiator or accelerator for polymerization of the monomer. The biologically active initiator or accelerator is a medicament that provides a desired medical or therapeutic activity as well as enhancing polymerization of the adhesive.

A method of forming a joint comprises the steps of: (a) at least filling a container with granular particles, the granular particles having a size of 0.25 mm to 1 mm; (b) inserting a component part into the container; and (c) at least partially filling the container containing this component part and the granular particles with a flowable, curable liquid, this liquid having curing time of less than 90 seconds. According to one embodiment of the present invention, the curable liquid has a gap fill of less than 0.25 mm and the curing time is less than about 5 seconds or less.

A cyanoacrylate adhesive is applied to non-suturable, non-sterile wound surfaces to protect and/or treat such surfaces, to promote wound healing and to retard infection of the wound.

A new material for the microencapsulation of biological systems was discovered and characterized with regards to the effects of reaction conditions on product yield. By using poly(cyanoacrylate ester), membrane microcapsules were produced with sufficient strength and porosity to be effective in a process environment for the immobilization and protection of encapsulated material. After synthesizing numerous monomeric cyanoacrylate esters, the n-butyl derivative was discovered to give the best results with regards to microcapsule formation.

Bloodstream infections related to use of catheters, particularly central-line catheters, are an important cause of patient morbidity, mortality, and increased health care costs. This study evaluated the efficacy of skin disinfection with chlorhexidine gluconate compared with povidone-iodine solution in preventing catheter-related bloodstream infection.