Biomedical

Disclosed are cyanoacrylate compositions comprising a compatible antimicrobial agent and, in particular, a compatible iodine containing antimicrobial agent. These compositions provide for in situ formation of an antimicrobial polymeric cyanoacrylate film on mammalian skin.

This study reports the effect of exposure to liquid carbon dioxide on the mechanical properties of selected medical polymers. The tensile strengths and moduli of fourteen polymers are reported. Materials were exposed to liquid CO2, or CO2 + trace amounts of aqueous H2O2, at 6.5 MPa and ambient temperature. Carbon dioxide uptake, swelling, and distortion were observed for the more amorphous polymers while polymers with higher crystallinity showed little effect from CO2 exposure.

A multi-layer, biodegradable film is disclosed. The multi-layer, biodegradable film contains a biodegradable core layer and a biodegradable pressure sensitive adhesive layer. The film may further contain a biodegradable, printable layer and a release liner.

An adhesive composition includes a polymerizable adhesive monomer and at least one dual finction stabilizer. The stabilizer provides superior stabilization and shelf-life of the composition, and enhances wound healing properties of the monomer composition.

A method of treating or preventing tinea cruris, commonly known as Jock Itch, includes applying a polymerizable monomer adhesive composition to an area of skin afflicted with or susceptible to tinea cruris, optionally with at least one of an additional anti-fungal agent or a skin care additive, and allowing the polymerizable monomer composition to polymerize to form a polymer film over the area of skin.

A cyanoacrylate adhesive is applied onto surface skin areas prone to ulceration or irritation so as to inhibit irritation of the surface skin due to contact with an artificial device such as prosthetic devices, bandages, casts, etc.

A cyanoacrylate adhesive is applied onto skin area prone to exposure to discharge by patients suffering from incontinence so as to shield the skin from direct contact with the discharge. The adhesive can also be applied over medicament that has been applied onto skin surface and onto skin along the periphery of a stoma.

A method of treating insect bites includes applying a polymerizable monomer adhesive composition to an area of skin afflicted with an insect bite, optionally with at least one of an additional active agent, and allowing the polymerizable monomer composition to polymerize to form a polymer film over the area of skin.

An adhesive composition that contains a preservative is particularly useful as a medical adhesive and can include alkyl cyanoacrylate monomers. The preservative is preferably soluble in the monomer. The compostion may optionally be sterilized by placing a mixture of a polymerizalble adhesive monomer and a preservative in a container, sealing the container and sterilizing the mixture and the container.