Biocompatible Monomer and Polymer Composition
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Year:
Abstract:
A biocompatible monomer composition contains (A) at least one monomer of the formula:
CHR=CXY
wherein X and Y are each strong electron withdrawing groups, and R is H or, provided that X and Y are both cyano groups, a C1-C4 alkyl group; and (B) an effective amount of at least one biocompatible agent effective to reduce active formaldehyde concentration levels, preferably an alpha-cyanoacrylate. The formaldehyde scavenger compound may be in microencapsulated form. the composition can be applied to a variety of materials and is particularly suitable as in vivo tissue adhesive. A method of joining together in vivo two surfaces, e.g., body tissues, includes (a) applying to at least one of the surfaces a composition containing 1) at least one monomer, preferably an alpha-cyanoacrlylate, which forms a polymer whose in vivo biodegradation produces formaldehyde; and 2) an effective amount of at least one biocompatible agent effective to reduce active formaldehyde concentration levels, preferably a formaldehyde scavenger; and (b) maintaining the surfaces in contact until the composition polymerizes.
Type of document:
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United States Patent [191
Leung et al.
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US005328687A
[11] Patent Number:
[45] Date of Patent:
5,328,687
[54] BIOCOMPATIBLE MONOMER AND
POLYMER COMPOSITIONS
[75] Inventors: Jeffrey C. Leung; Jeffrey G. Clark,
both of Raleigh, N.C.
[73] Assignee: Tri-Point Medical L.P., Raleigh,
N.C.
[21] App]. No.: 40,618
[22] Filed: Mar. 31, 1993
[51] Int. Cl.5 ..................... .. A61K 31/74; A61K 9/14;
C08F 120/44; C08F 222/34
[52] U.S. Cl. ............................... .. 424/78.35; 424/423;
424/451; 424/489; 514/963
[58] Field of Search ................... .. 424/423, 78.35, 451,
424/489; 526/297, 300, 341; 606/228; 514/963;
264/4.1, 4.3, 4.6
[56] References Cited
U.S. PATENT DOCUMENTS
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4,127,382 11/1978 Perry ..................................... .. 8/181
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FOREIGN PATENT DOCUMENTS
1162904 2/1984 Canada.
0138448 4/1985 European Pat. Off. .
OTHER PUBLICATIONS
“Methods of Abating Residual Formaldehyde in Indus-
trial Resins”, EPO Applied Technology Series vol. 10.
“Synthesis and Degradation of Poly(all
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