Biomedical

A cyanoacrylate adhesive is applied to non-suturable, non-sterile wound surfaces to protect and/or treat such surfaces, to promote wound healing and to retard infection of the wound.

Fluorinated cyanoacrylates having the formula:

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wherein R is hydrogen, methyl or ethyl, R' is fluorine, -CF3 or -(CF2)nH, and n is an integer from 1 to 3 have been found to be useful adhesives which when applied as monomers to adherends rapidly polymerize in the presence of even small amounts of e.g. moisture to form strong bonds. The monomers also polymerize to films and can be used biologically as hemostatics and tissue adhesives.

A novel improved gypsum board having improved antifungal properties is disclosed. The board comprises a gypsum core, front and back paper facings and a polymeric antifungal agent effective at inhibiting fungal growth. A preferred polymeric antifungal agent is polyDADMAC or polyTMMC. In addition to the polymeric antifungal agent, a non-polymeric antifungal agent, such as cetyl pyridinium chloride, sodium or zinc pyrithione, or both, may be included. The polymeric antifungal agent can be present in the gypsum core and/or on one or both of the paper facings.

2-Cyanoacrylate represented by the formula:

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A process is provided for the reversible coupling of weak nucleophiles to the carbon-carbon double bond of 2-cyanoacrylic acid or an ester thereof so as to reversibly protect the bond. Examples of weak nucleophiles include alcohols (including diols and polyols), phenols, sulfur nucleophiles such as thiols and thio acids, phosphorus nucleophiles such as dialkyl or diarylphosphites and phosphines, and carbon nucleophiles such as active methylene compounds.

OBJECTIVES/HYPOTHESIS Numerous methods are used in the correction of deviated septal cartilage. One of these methods is to perform partial-thickness incisions (scoring) on the concave side of the deviated cartilage. In this retrospective report, we present a series of patients who were treated by filling the scoring incision gaps with cyanoacrylate-based tissue adhesives to increase the effectiveness of scoring incisions and to maintain stability of the corrected concave cartilage segments.

Disclosed are methods and formulations for the treatment or prevention of infections on mammalian tissues such as skin. Specifically, the methods of this invention involve the in situ formation of a polymeric cyanoacrylate film containing mixed antibiotics over mammalian tissue.

The present invention relates to the use, for treating the hair, of a composition containing, in a cosmetically acceptable medium, at least one monomer capable of polymerizing by anionic polymerization in the presence of a nucleophilc agent.

Flame retardant compositions are disclosed which comprise (a) at least one particulate material which expands on the application of heat and (b) at least one particulate nano-filler, together with at least one polymer and/or at least one curable monomer or oligomer. The compositions may also contain certain silicon-based materials. Flame-retardant compositions comprising polyorganosiloxanes containing one or more functional groups selected from amino, hydroxyl, methacrylic, acrylic and epoxy groups, are also disclosed.

This invention relates to the preparation of monomeric α-cyanoacrylates and is particularly concerned with the preparation in improved yiled monomeric α-cyanoacrylates useful as adhesive compositions.